2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135025
    5-Fluoro-3,5-ADB-PFUPPYCA
    5-Fluoro-3,5-ADB-PFUPPYCA is structurally classified as a synthetic cannabinoid.
    5-Fluoro-3,5-ADB-PFUPPYCA
  • HY-170720
    CH-FUBIATA
    CH-FUBIATA is structurally similar to known synthetic cannabinoids.
    CH-FUBIATA
  • HY-W783639S
    Bzo-poxizid-d9
    Bzo-poxizid-d9 (5C-MDA-19-d9, Petyl MDA-19-d9) is deuterium labeled Bzo-poxizid. Bzo-poxizid is a synthetic cannabinoid that is a psychoactive substance.
    Bzo-poxizid-d<sub>9</sub>
  • HY-158814
    2-(2-Chlorophenyl)-1-(1H-indol-3-yl)ethanone
    2-(2-Chlorophenyl)-1-(1H-indol-3-yl)ethanone is a precursor in the synthesis of synthetic cannabinoids.
    2-(2-Chlorophenyl)-1-(1H-indol-3-yl)ethanone
  • HY-170744
    (±)-Cannabichromebutolic acid
    (±)-Cannabichromebutolic acid is structurally similar to known phytocannabinoids.
    (±)-Cannabichromebutolic acid
  • HY-122799
    Cannabigerovarinic acid
    		Control
    Cannabigerovarinic acid is a cannabinoid acid, which is found in Thai Cannabis.
    Cannabigerovarinic acid
  • HY-168792
    (±)-9-Nor-9α-hydroxy Hexahydrocannabinol
    (±)-9-Nor-9α-hydroxy Hexahydrocannabinol is a cannabinoid-type compound that has strong cannabinoid-like activity in both dogs and mice.
    (±)-9-Nor-9α-hydroxy Hexahydrocannabinol
  • HY-170042A
    5'-Hydroxy-9(R)-hexahydrocannabinol
    5'-Hydroxy-9(R)-hexahydrocannabinol is a phytocannabinoid metabolite.
    5'-Hydroxy-9(R)-hexahydrocannabinol
  • HY-168355
    Δ8-THC methyl ether
    		Ligand
    Δ8-THC methyl ether (compound 3) shows a good docking score (-10.167 kcal/mol) for CB2 receptor. Δ8-THC methyl ether has antinociceptive activity in mice.
    Δ8-THC methyl ether
  • HY-158943
    2-Fluoro QMPSB
    2-Fluoro QMPSB (QMDFPSB) is structurally similar to known synthetic cannabinoids.
    2-Fluoro QMPSB
  • HY-170045
    (±)-9α-Hydroxy hexahydrocannabinol
    (±)-9α-Hydroxy hexahydrocannabinol ((±)-9α-Hydroxy HHC) is structurally similar to known phytocannabinoids.
    (±)-9α-Hydroxy hexahydrocannabinol
  • HY-129787
    PF-03550096
    		Agonist
    PF-03550096 is an orally active synthetic cannabinoid (CB) that selectively targets peripheral CB2 receptors with a Ki value of 7.9 nM. PF-03550096 has analgesic activity.
    PF-03550096
  • HY-141411B
    (R)-Zevaquenabant
    		Antagonist
    (R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant (HY-141411A). Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual cannabinoid CB1 receptor and inducible NOS antagonist. Zevaquenabant ameliorates obesity-induced chronic kidney disease (CKD).
    (R)-Zevaquenabant
  • HY-172073
    MDMB-FUBICA metabolite 3
    MDMB-FUBICA metabolite 3 is structurally classified as a synthetic cannabinoid. MDMB-FUBICA metabolite 3 is a metabolite of MDMB-FUBICA.
    MDMB-FUBICA metabolite 3
  • HY-170666
    Afubiata
    Afubiata is structurally similar to known synthetic cannabinoids.
    Afubiata
  • HY-168788
    8(S)-Hydroxy-9(R)-hexahydrocannabinol
    8(S)-Hydroxy-9(R)-hexahydrocannabinol is structurally similar to known phytocannabinoids.
    8(S)-Hydroxy-9(R)-hexahydrocannabinol
  • HY-W783639
    Bzo-poxizid
    Bzo-poxizid is a synthetic cannabinoid that is a psychoactive substance.
    Bzo-poxizid
  • HY-157312
    TM38837
    		Inhibitor
    CB1 antagonist 4 is a inverse agonist of cannabinoid receptor 1 (CB1) with an IC50 of 0.4 nM. CB1 antagonist 4 can reduce body weight, improve plasma inflammatory markers and glucose homeostasis.
    TM38837
  • HY-168793
    (±)-9-Nor-9β-hydroxy Hexahydrocannabinol
    (±)-9-Nor-9β-hydroxy Hexahydrocannabinol is structurally similar to known synthetic cannabinoids.
    (±)-9-Nor-9β-hydroxy Hexahydrocannabinol
  • HY-158836
    NAPIE
    NAPIE is structurally similar to known synthetic cannabinoids.
    NAPIE
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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